Author(s): Nina Hassani, Maryvonne Jurdan, Peter Kessler, Lilie Scaramozzino , Salah-Eddine Hassani, Bruno Bioulac
Objective: This study aims to evaluate the safety and efficacy of EZPRF (plasma rich in fibrin) and EZGEL (albumin gel and platelet rich fibrin) in reducing moderate to severe nasolabial folds over a six-month follow-up period.
Materials and methods: A multicentric study was conducted involving 25 patients aged 35 to 80 years, divided into two groups: Group 1 received a single treatment, while Group 2 received an additional treatment after one month. Injections were assessed using the Wrinkle Severity Rating Scale (WSRS) and the Global Aesthetic Improvement Scale (GAIS).
Results: Group 1 (mean age 53 years and mean WSRS at 2.5) showed a 50% reduction in nasolabial fold depth after one month, with sustained improvements of 40% at three months and 30% at six months. Group 2 (mean age 60 years and mean WSRS at 3.07) reported a 32% reduction at one month, 48% at three months, and 38% at six months. Both groups exhibited high satisfaction levels, with minimal side effects, primarily consisting of bruising and slight swelling.
Conclusions: The results indicate that EZPRF and EZGEL are ideal biomaterials for facial repair and regeneration, providing natural and lasting results. It is recommended to repeat the treatment after one month, particularly for elderly patients with high WSRS scores. These treatments are safe, well-tolerated, and contribute to a significant improvement in the appearance of nasolabial folds.
